| First Author | Guazzi S | Year | 1990 |
| Journal | EMBO J | Volume | 9 |
| Issue | 11 | Pages | 3631-9 |
| PubMed ID | 1976511 | Mgi Jnum | J:10764 |
| Mgi Id | MGI:59210 | Doi | 10.1002/j.1460-2075.1990.tb07574.x |
| Citation | Guazzi S, et al. (1990) Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J 9(11):3631-9 |
| abstractText | The cDNA for TTF-1, a thyroid nuclear factor that binds to the promoter of thyroid specific genes, has been cloned. The protein encoded by the cDNA shows binding properties indistinguishable from those of TTF-1 present in nuclear extracts of differentiated rat thyroid cells. The DNA binding domain of TTF-1 is a novel mammalian homeodomain that shows considerable sequence homology to the Drosophila NK-2 homeodomain. TTF-1 mRNA and corresponding binding activity are detected in thyroid and lung. The chromosomal localization of the TTF-1 gene has been determined in humans and mice and corresponds to chromosomes 14 and 12, respectively, demonstrating that the TTF-1 gene is not located within previously described clusters of homeobox-containing genes. |
