| Primary Identifier | IPR042188 | Type | Homologous_superfamily |
| Short Name | MmgE/PrpD_sf_2 |
| description | MmgE/PrpD superfamily members include 2-methylcitrate dehydratase (PrpD; ) and citrate/2-methylcitrate dehydratase MmgE. PrpD is required for propionate catabolism, catalysing the third step of the 2-methylcitric acid cycle []. This enzyme consists of two domains: a large domain with an all-helical fold and a smaller domain that folds into an alpha beta domain []. Cis-aconitic acid decarboxylase (CAD) shares high identity with proteins of the MmgE/PrpD family. CAD is essential for itaconic acid production in Aspergillus terreus [].This superfamily represents the small domain found in PrpD. |
