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Publication : Genomic dark matter sheds light on EVI1-driven leukemia.

First Author  Koche RP Year  2014
Journal  Cancer Cell Volume  25
Issue  4 Pages  407-8
PubMed ID  24735919 Mgi Jnum  J:210805
Mgi Id  MGI:5571932 Doi  10.1016/j.ccr.2014.03.031
Citation  Koche RP, et al. (2014) Genomic dark matter sheds light on EVI1-driven leukemia. Cancer Cell 25(4):407-8
abstractText  The orchestration of transcriptional programs depends on proper gene-enhancer pairing. While much remains to be learned about this process in normal development, two recent studies in Cell (Groschel and colleagues) and this issue of Cancer Cell (Yamazaki and colleagues) highlight how the genomic rearrangement of an enhancer plays a causal role in the onset of a leukemogenic program.
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