First Author | Koche RP | Year | 2014 |
Journal | Cancer Cell | Volume | 25 |
Issue | 4 | Pages | 407-8 |
PubMed ID | 24735919 | Mgi Jnum | J:210805 |
Mgi Id | MGI:5571932 | Doi | 10.1016/j.ccr.2014.03.031 |
Citation | Koche RP, et al. (2014) Genomic dark matter sheds light on EVI1-driven leukemia. Cancer Cell 25(4):407-8 |
abstractText | The orchestration of transcriptional programs depends on proper gene-enhancer pairing. While much remains to be learned about this process in normal development, two recent studies in Cell (Groschel and colleagues) and this issue of Cancer Cell (Yamazaki and colleagues) highlight how the genomic rearrangement of an enhancer plays a causal role in the onset of a leukemogenic program. |