| First Author | Carty SA | Year | 2018 |
| Journal | J Immunol | Volume | 200 |
| Issue | 1 | Pages | 82-91 |
| PubMed ID | 29150566 | Mgi Jnum | J:253340 |
| Mgi Id | MGI:6108079 | Doi | 10.4049/jimmunol.1700559 |
| Citation | Carty SA, et al. (2018) The Loss of TET2 Promotes CD8(+) T Cell Memory Differentiation. J Immunol 200(1):82-91 |
| abstractText | T cell differentiation requires appropriate regulation of DNA methylation. In this article, we demonstrate that the methylcytosine dioxygenase ten-eleven translocation (TET)2 regulates CD8(+) T cell differentiation. In a murine model of acute viral infection, TET2 loss promotes early acquisition of a memory CD8(+) T cell fate in a cell-intrinsic manner without disrupting Ag-driven cell expansion or effector function. Upon secondary recall, TET2-deficient memory CD8(+) T cells demonstrate superior pathogen control. Genome-wide methylation analysis identified a number of differentially methylated regions in TET2-deficient versus wild-type CD8(+) T cells. These differentially methylated regions did not occur at the loci of differentially expressed memory markers; rather, several hypermethylated regions were identified in known transcriptional regulators of CD8(+) T cell memory fate. Together, these data demonstrate that TET2 is an important regulator of CD8(+) T cell fate decisions. |
