| First Author | Cai X | Year | 2023 |
| Journal | Int J Mol Sci | Volume | 24 |
| Issue | 14 | PubMed ID | 37511396 |
| Mgi Jnum | J:339178 | Mgi Id | MGI:7516233 |
| Doi | 10.3390/ijms241411638 | Citation | Cai X, et al. (2023) GSK3beta Inhibition Ameliorates Atherosclerotic Calcification. Int J Mol Sci 24(14) |
| abstractText | Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to atherosclerotic calcification. In a previous study, we showed that glycogen synthase kinase-3beta (GSK3beta) inhibition induced beta-catenin and reduced mothers against DPP homolog 1 (SMAD1) in order to redirect osteoblast-like cells towards endothelial lineage, thereby reducing vascular calcification in Matrix Gla Protein (Mgp) deficiency and diabetic Ins2(Akita/wt) mice. Here, we report that GSK3beta inhibition or endothelial-specific deletion of GSK3beta reduces atherosclerotic calcification. We also find that alterations in beta-catenin and SMAD1 induced by GSK3beta inhibition in the aortas of Apoe(-/-) mice are similar to Mgp(-/-) mice. Together, our results suggest that GSK3beta inhibition reduces vascular calcification in atherosclerotic lesions through a similar mechanism to that in Mgp(-/-) mice. |
