| First Author | Wang Q | Year | 2001 |
| Journal | J Exp Med | Volume | 194 |
| Issue | 12 | Pages | 1721-30 |
| PubMed ID | 11748274 | Mgi Jnum | J:73479 |
| Mgi Id | MGI:2155536 | Doi | 10.1084/jem.194.12.1721 |
| Citation | Wang Q, et al. (2001) Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene. J Exp Med 194(12):1721-30 |
| abstractText | Absence of CD4 impairs the efficiency of T cell receptor (TCR) signaling in response to major histocompatibility complex (MHC) class II-presented peptides. Here we use mice carrying a conditional Cd4 allele to study the consequences of impaired TCR signaling after the completion of thymocyte development. We show that loss of CD4 decreases the steady-state proliferation of T cells as monitored by in vivo labeling with bromo-deoxyuridine. Moreover, T cells lacking CD4 compete poorly with CD4-expressing T cells during proliferative expansion after transfer into lymphopenic recipients. The data suggest that T cells compete with one another during homeostatic proliferation, and indicate that the basis of this competition is TCR signaling. |
