| First Author | Takeshita T | Year | 1996 |
| Journal | Biochem Biophys Res Commun | Volume | 225 |
| Issue | 3 | Pages | 1035-9 |
| PubMed ID | 8780729 | Mgi Jnum | J:51739 |
| Mgi Id | MGI:1326798 | Doi | 10.1006/bbrc.1996.1290 |
| Citation | Takeshita T, et al. (1996) Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. Biochem Biophys Res Commun 225(3):1035-9 |
| abstractText | We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phospho-rylated rapidly after stimulation with various cytokines such as IL-2, IL-3, IL-4, IL-7, GM- CSF, EGF and PDGF. STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors. |
