| First Author | Kraal G | Year | 1988 |
| Journal | Am J Anat | Volume | 182 |
| Issue | 2 | Pages | 148-54 |
| PubMed ID | 3400622 | Mgi Jnum | J:27108 |
| Mgi Id | MGI:74526 | Doi | 10.1002/aja.1001820205 |
| Citation | Kraal G, et al. (1988) Splenic microenvironment of the CBA/N mouse: immunohistochemical analysis using monoclonal antibodies against lymphocytes and nonlymphoid cells. Am J Anat 182(2):148-54 |
| abstractText | CBA/N mice carry an X-linked immune-deficiency gene, leading to a defect in the ability to form antibodies against T-independent type 2 antigens. By using immunohistochemistry, the organization of the spleen of the immune-deficient male (xid) CBA/N F1 and the normal female F1 were compared. Staining with antilymphocyte markers showed that the total number of cells in the various T- and B-cell areas was smaller in the xid mouse, resulting in very small white pulp compartments. Fewer B cells were seen in the marginal zone. When the spleens of the F1 mice were examined for macrophage markers, the rings of marginal-zone macrophages and the ring of marginal metallophilic macrophages were much thinner in the xid mouse. In particular, the marginal-zone macrophages are thought to play a role in the response against thymus-independent type 2 antigens, and their small numbers in the xid mouse are suggestive of a role for the microenvironment in the defects in these mice. |
