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Protein Coding Gene : Map3k8 mitogen-activated protein kinase kinase kinase 8

Primary Identifier  MGI:1346878 Organism  mouse, laboratory
Chromosome  18 NCBI Gene Number  26410
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in gap junction-mediated intercellular transport. Predicted to act upstream of or within immune system process. Predicted to be located in cytosol. Is expressed in several structures, including adipose tissue; adrenal gland; alimentary system; hemolymphoid system gland; and reproductive system. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma; lung cancer; and stomach cancer. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8).
PHENOTYPE: Mutant mice resist endotoxic shock. Their MHC II expression is enhanced. Macrophages' TNF-alpha response to viruses and to all TLR ligands is impaired. Macrophage and T-cell secretion of other cytokines in response to various TLR ligands or OVA is aberrant. Anti-OVA Ig classes are abnormally skewed. [provided by MGI curators]
  • synonyms:
  • Cot/Tpl2,
  • Map3k8,
  • MGI:98808,
  • cancer Osaka thyroid, oncogene,
  • MGI:88472,
  • tumor progression locus 2,
  • Cot,
  • Tpl2,
  • mitogen-activated protein kinase kinase kinase 8,
  • c-COT,
  • MGD-MRK-15201,
  • Tpl-2,
  • MGD-MRK-2095

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Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

29 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For