| Primary Identifier | IPR016441 | Type | Family |
| Short Name | Tti1 |
| description | This entry includes yeast TEL2-interacting protein 1 (Tti1) and its homologues from animals. Budding yeast Tti1 is a subunit of the ASTRA complex, which is involved in chromatin remodelling []. Human Tti1 homologue is part of the TTT complex that is required to stabilise protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC) []. |
