| First Author | Akira S | Year | 2000 |
| Journal | Curr Opin Immunol | Volume | 12 |
| Issue | 1 | Pages | 59-63 |
| PubMed ID | 10679398 | Mgi Jnum | J:60336 |
| Mgi Id | MGI:1353182 | Doi | 10.1016/s0952-7915(99)00051-5 |
| Citation | Akira S (2000) The role of IL-18 in innate immunity. Curr Opin Immunol 12(1):59-63 |
| abstractText | IL-18 - a novel cytokine with potent IFN-gamma-inducing activities - plays an important role in the Th1-mediated immune response in collaboration with IL-12. IL-18 is a member of the IL-1 family. The IL-18 receptor system and its signal transduction pathway are analogous to those of the IL-1 receptor. Mice deficient in IL-18 have demonstrated its critical role in natural killer cell activity and in vivo Th1 response. |
