| First Author | Nakayama Y | Year | 1991 |
| Journal | Eur J Biochem | Volume | 202 |
| Issue | 2 | Pages | 569-74 |
| PubMed ID | 1761056 | Mgi Jnum | J:2826 |
| Mgi Id | MGI:59977 | Doi | 10.1111/j.1432-1033.1991.tb16409.x |
| Citation | Nakayama Y, et al. (1991) The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast. Eur J Biochem 202(2):569-74 |
| abstractText | We have cloned and sequenced mouse brain AP47, the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The predicted protein sequence of AP47 is closely related to rat and calf brain AP50, the corresponding medium chain of the plasma-membrane clathrin-associated protein complex AP-2. We have also identified in the yeast genome an open reading frame encoding a protein of previously unknown function. Referred to here as YAP54, its predicted protein sequence displays a striking homology to AP47. We therefore propose that Yap54 is the medium chain subunit of a putative AP-1 complex in yeast. From the analyses of the optimized sequence alignments of AP47, AP50 and Yap54p, we suggest a model for the domain organization of the medium chains. |
