| First Author | Baker SM | Year | 1995 |
| Journal | Cell | Volume | 82 |
| Issue | 2 | Pages | 309-19 |
| PubMed ID | 7628019 | Mgi Jnum | J:27389 |
| Mgi Id | MGI:74827 | Doi | 10.1016/0092-8674(95)90318-6 |
| Citation | Baker SM, et al. (1995) Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell 82(2):309-19 |
| abstractText | Using gene targeting in embryonic stem cells, we have derived mice with a null mutation in a DNA mismatch repair gene homolog, PMS2. We observed microsatellite instability in the male germline, in tail, and in tumor DNA of PMS2-deficient animals. We therefore conclude that PMS2 is involved in DNA mismatch repair in a variety of tissues. PMS2-deficient animals appear prone to sarcomas and lymphomas. PMS2-deficient males are infertile, producing only abnormal spermatozoa. Analysis of axial element and synaptonemal complex formation during prophase of meiosis I indicates abnormalities in chromosome synapsis. These observations suggest links among mismatch repair, genetic recombination, and chromosome synapsis in meiosis. |
