Primary Identifier | MGI:107678 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 20537 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables glucose:sodium symporter activity. Involved in intestinal D-glucose absorption and renal glucose absorption. Acts upstream of or within glucose transmembrane transport; intestinal absorption; and metanephros development. Located in apical plasma membrane and brush border. Is expressed in alimentary system; brain; and urinary system. Orthologous to human SLC5A1 (solute carrier family 5 member 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit lethality unless maintained on a glucose-galatose-free diet, distended intestine, impaired glucose transport across the brush border membrane and impaired renal glucose reabsorption. [provided by MGI curators] |