| First Author | Cushman LJ | Year | 2000 |
| Journal | Genesis | Volume | 28 |
| Issue | 3-4 | Pages | 167-74 |
| PubMed ID | 11105060 | Mgi Jnum | J:66897 |
| Mgi Id | MGI:1929397 | Doi | 10.1002/1526-968x(200011/12)28:3/4<167::aid-gene120>3.0.co;2-n |
| Citation | Cushman LJ, et al. (2000) Cre-mediated recombination in the pituitary gland. Genesis 28(3-4):167-74 |
| abstractText | Summary: Organ-specific expression of a cre recombinase transgene allows for the analysis of gene function in a particular tissue or cell type. Using a 4.6 kb promoter from the mouse glycoprotein hormone alpha-subunit (alphaGSU or Cga) gene, we have generated and characterized a line of transgenic mice that express cre recombinase in the anterior and intermediate lobes of the pituitary gland. Utilizing a cre-responsive reporter transgene, alphaGSU-cre transgene expression was detected in the pituitary primordium and in all five cell types of the adult anterior pituitary. alphaGSU-cre transgene activity was also detected in the cardiac and skeletal muscle. Little or no activity was evident in the gonads, adrenal glands, brain, ventromedial hypothalamus, or kidneys. The alphaGSU-cre transgenic mice characterized here will be a valuable tool for examining gene function in the pituitary gland. genesis 28:167-174, 2000. Copyright 2000 Wiley-Liss, Inc. |
