| First Author | Nguyen TT | Year | 2017 |
| Journal | Nat Immunol | Volume | 18 |
| Issue | 3 | Pages | 321-333 |
| PubMed ID | 28135254 | Mgi Jnum | J:240689 |
| Mgi Id | MGI:5888941 | Doi | 10.1038/ni.3677 |
| Citation | Nguyen TT, et al. (2017) The IgM receptor FcmuR limits tonic BCR signaling by regulating expression of the IgM BCR. Nat Immunol 18(3):321-333 |
| abstractText | The FcmuR receptor for the crystallizable fragment (Fc) of immunoglobulin M (IgM) can function as a cell-surface receptor for secreted IgM on a variety of cell types. We found here that FcmuR was also expressed in the trans-Golgi network of developing B cells, where it constrained transport of the IgM-isotype BCR (IgM-BCR) but not of the IgD-isotype BCR (IgD-BCR). In the absence of FcmuR, the surface expression of IgM-BCR was increased, which resulted in enhanced tonic BCR signaling. B-cell-specific deficiency in FcmuR enhanced the spontaneous differentiation of B-1 cells, which resulted in increased serum concentrations of natural IgM and dysregulated homeostasis of B-2 cells; this caused the spontaneous formation of germinal centers, increased titers of serum autoantibodies and excessive accumulation of B cells. Thus, FcmuR serves as a critical regulator of B cell biology by constraining the transport and cell-surface expression of IgM-BCR. |
