| Primary Identifier | IPR033027 | Type | Family |
| Short Name | DSCAM_metazoan |
| description | Cell adhesion molecule DSCAM is a cell adhesion molecule that plays a role in axon guidance, self-avoidance and synaptic formation [, , , , ]. It is a receptor for netrin, acting independently of and in collaboration with DCC []. DSCAM is one of the largest Immunoglobulin (Ig) superfamily CAMs, containing 10 Ig domains and six fibronectin type III (FN) repeats [], and contributes to defects in the central nervous system in Down syndrome patients []. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene []. Drosophila Dscam2 is also alternatively spliced and plays a crucial role in the development of two visual system neurons, monopolar cells L1 and L2 []. |
