| First Author | Brown MR | Year | 2010 |
| Journal | Nat Neurosci | Volume | 13 |
| Issue | 7 | Pages | 819-21 |
| PubMed ID | 20512134 | Mgi Jnum | J:161627 |
| Mgi Id | MGI:4460052 | Doi | 10.1038/nn.2563 |
| Citation | Brown MR, et al. (2010) Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack. Nat Neurosci 13(7):819-21 |
| abstractText | In humans, the absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome, the most common inherited form of intellectual disability. Using biochemical and electrophysiological studies, we found that FMRP binds to the C terminus of the Slack sodium-activated potassium channel to activate the channel in mice. Our findings suggest that Slack activity provides a link between patterns of neuronal firing and changes in protein translation. |
