First Author | West JD | Year | 1985 |
Journal | Mouse News Lett | Volume | 72 |
Pages | 106 | Mgi Jnum | J:65315 |
Mgi Id | MGI:1926309 | Citation | West JD, et al. (1985) Mitfmi-di - microphthalmia-defective iris. Mouse News Lett 72:106 |
abstractText | Full text of MNL contribution: 11. A new microphthalmia allele: mi<di>. A new allele of microphthalmia (mi) was discovered among the progeny of a C3H/HeH male that had been treated with 250 mg/kg of ethylnitrosourea and mated to an outbred PT strain female. Homozygotes have white coats, small eyes with very little pigmentation and abnormal retinae and irises. Iris pigment is restricted to a rim around the pupil. Genetic studies showed that the mutation was an allele of the mi locus and we designate the new allele microphthalmia-defective iris (mi<di>). Some mi<di>/+ heterozygotes (including the original mutant animal) show a bright "red-reflex" when light is shone directly into the eye and this may be caused by reduced choroidal pigmentation. Otherwise mi<di>/+ mice appear normal. Partial complementation occurs in mi<di>/Mi<wh> compound heterozygotes with respect to eye size. (West and Fisher) |