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Publication : Phosphorylation of DeltaFosB mediates its stability in vivo.

First Author  Ulery-Reynolds PG Year  2009
Journal  Neuroscience Volume  158
Issue  2 Pages  369-72
PubMed ID  19041372 Mgi Jnum  J:146079
Mgi Id  MGI:3836668 Doi  10.1016/j.neuroscience.2008.10.059
Citation  Ulery-Reynolds PG, et al. (2009) Phosphorylation of DeltaFosB mediates its stability in vivo. Neuroscience 158(2):369-72
abstractText  The transcription factor, DeltaFosB, accumulates in a region-specific manner in brain in response to many types of chronic stimulation due to the unusual stability of the protein. The phosphorylation of Ser27 in DeltaFosB has been shown to promote this stability in vitro. We show here that this phosphorylation reaction is also important for DeltaFosB's stability in the brain in vivo and for the unique behavioral plasticity mediated by this transcription factor.
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