| First Author | Hoshi T | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 23 | Pages | 3749-54 |
| PubMed ID | 24140340 | Mgi Jnum | J:202742 |
| Mgi Id | MGI:5521402 | Doi | 10.1016/j.febslet.2013.10.001 |
| Citation | Hoshi T, et al. (2013) Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes. FEBS Lett 587(23):3749-54 |
| abstractText | Low-density lipoprotein receptor-related protein 4 (Lrp4) is essential for pre- and post-synaptic specialization at the neuromuscular junction (NMJ), an indispensable synapse between a motor nerve and skeletal muscle. Muscle-specific receptor tyrosine kinase MuSK must form a complex with Lrp4 to organize postsynaptic specialization at NMJs. Here, we show that the chaperon Mesdc2 binds to the intracellular form of Lrp4 and promotes its glycosylation and cell-surface expression. Furthermore, knockdown of Mesdc2 suppresses cell-surface expression of Lrp4, activation of MuSK, and postsynaptic specialization in muscle cells. These results suggest that Mesdc2 plays an essential role in NMJ formation by promoting Lrp4 maturation. |
