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Publication : Isolation and characterization of the MHC linked beta-type proteasome subunit MC13 cDNA.

First Author  Frentzel S Year  1992
Journal  FEBS Lett Volume  302
Issue  2 Pages  121-5
PubMed ID  1633842 Mgi Jnum  J:954
Mgi Id  MGI:49486 Doi  10.1016/0014-5793(92)80420-l
Citation  Frentzel S, et al. (1992) Isolation and characterization of the MHC linked beta-type proteasome subunit MC13 cDNA. FEBS Lett 302(2):121-5
abstractText  We have cloned and analysed the second mouse MHC-linked proteasome subunit, designated MC13, which appears to be homologous to the human RING10 proteasome protein. The isolated cDNA has an ORF encoding a protein of 276 amino acids with a molecular weight of ca. 30 kDa. Sequence alignment reveals that the subunit MC13 and several other mammalian proteasome subunits are encoded by a second proteasome gene family. This second gene family encodes subunits of the beta-type, reveals striking sequence similarities with the beta-subunit of archaebacterial proteasomes and is related to, but distinct from, the genes encoding the so-called alpha-type subunits.
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