| First Author | Gong Q | Year | 1997 |
| Journal | Immunity | Volume | 7 |
| Issue | 3 | Pages | 369-77 |
| PubMed ID | 9324357 | Mgi Jnum | J:43156 |
| Mgi Id | MGI:1097216 | Doi | 10.1016/s1074-7613(00)80358-1 |
| Citation | Gong Q, et al. (1997) Restoration of thymocyte development and function in zap-70-/- mice by the Syk protein tyrosine kinase. Immunity 7(3):369-77 |
| abstractText | The Syk family of protein tyrosine kinases, consisting of ZAP-70 and Syk, associate with the pre- and alphabeta T cell antigen receptors (TCRs) and undergo tyrosine phosphorylation and activation following receptor engagement. Thymocyte development in zap-70-/- mice is blocked at the CD4+CD8+ TCR(lo) stage. The presence of Syk in the thymus has raised the possibility that Syk may be able to mediate TCR function. To determine if Syk can play a role in thymocyte development, we generated zap-70-/- mice expressing a human syk cDNA. Syk expression restored both thymocyte development and function. In addition, Syk function required the CD45 transmembrane protein tyrosine phosphatase. Hence, ZAP-70 and Syk can play overlapping functions and exhibit similar regulatory mechanisms in mediating alphabeta T cell development. |
