| First Author | Liou GY | Year | 2016 |
| Journal | Cell Rep | Volume | 14 |
| Issue | 10 | Pages | 2325-36 |
| PubMed ID | 26947075 | Mgi Jnum | J:234564 |
| Mgi Id | MGI:5790272 | Doi | 10.1016/j.celrep.2016.02.029 |
| Citation | Liou GY, et al. (2016) Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions. Cell Rep 14(10):2325-36 |
| abstractText | The development of pancreatic cancer requires the acquisition of oncogenic KRas mutations and upregulation of growth factor signaling, but the relationship between these is not well established. Here, we show that mutant KRas alters mitochondrial metabolism in pancreatic acinar cells, resulting in increased generation of mitochondrial reactive oxygen species (mROS). Mitochondrial ROS then drives the dedifferentiation of acinar cells to a duct-like progenitor phenotype and progression to PanIN. This is mediated via the ROS-receptive kinase protein kinase D1 and the transcription factors NF-kappaB1 and NF-kappaB2, which upregulate expression of the epidermal growth factor, its ligands, and their sheddase ADAM17. In vivo, interception of KRas-mediated generation of mROS reduced the formation of pre-neoplastic lesions. Hence, our data provide insight into how oncogenic KRas interacts with growth factor signaling to induce the formation of pancreatic cancer. |
