| Primary Identifier | MGI:2685574 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 432611 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable dynein heavy chain binding activity; dynein light chain binding activity; and microtubule motor activity. Predicted to be involved in cilium movement and outer dynein arm assembly. Predicted to act upstream of or within cilium assembly and determination of left/right symmetry. Located in 9+2 motile cilium; axoneme; and external side of plasma membrane. Is expressed in spermatozoon and testis. Used to study Kartagener syndrome and primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2). PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit situs inversus totalis and immotile respiratory cilia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
