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Comment :

Type  MGI:General Description  cortical bone density is moderately reduced in sham-operated mice and is significantly lower in mutant females with or without Ovx or pregnancy in ovarectomized (Ovx) wild-type females, trabecular bone density is reduced by 43%, but is unchanged in Ovx mutants trabecular bone density is increased in Ovx wild-type and mutant females after estradiol treatment; with pregnancy, trabecular bone density is increased by 36% in pregnant mutants and by 53% in pregnant wild-type on a high-calcium diet, there is a less marked reduction of cortical bone density in lactating mutant females (4% in lactating vs 10-13% in mutants on a normal diet); trabecular bone density is reduced in lactating mice