| Primary Identifier | IPR013926 | Type | Family |
| Short Name | CGI121/TPRKB |
| description | This entry represents the EKC/KEOPS complex subunit Cgi121 from fungi and its homologue, TPRKB from mammals. This entry also includes archaeal homologues []. CGI121 is part of the KEOPS complex, which is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine []. The KEOPS complex also plays an important part in telomere uncapping and telomere elongation and is required for efficient recruitment of transcriptional coactivators []. TPRKB has been shown to bind to the p53-related protein kinase (PRPK) []. PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. |
