Primary Identifier | MGI:1921472 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 74222 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable GTPase activity and molecular adaptor activity. Involved in neuron migration. Located in several cellular components, including dendrite; perikaryon; and perinuclear region of cytoplasm. Is expressed in cerebral cortex and testis. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human SEPTIN14 (septin 14). PHENOTYPE: Mice homozygous for a null allele display enhanced thigmotaxis behavior and impaired cued conditioning behavior. Mice homozygous for a second null allele display decreased hematocrit and hemoglobin levels and cataracts. [provided by MGI curators] |