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Protein Coding Gene : Grb7 growth factor receptor bound protein 7

Primary Identifier  MGI:102683 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  14786
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable identical protein binding activity; phosphatidylinositol binding activity; and protein kinase binding activity. Involved in negative regulation of translation and stress granule assembly. Located in cytoplasmic stress granule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in esophagus adenocarcinoma. Orthologous to human GRB7 (growth factor receptor bound protein 7).
PHENOTYPE: Mice homozygous for a knock-out allele are viable and survive to adulthood with no overt abnormalities. However, litters born to knockout females fail to thrive to weaning age. [provided by MGI curators]
  • synonyms:
  • Grb7,
  • MGD-MRK-19586,
  • growth factor receptor bound protein 7

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

18 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For