Primary Identifier | MGI:1921353 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 74103 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable actin filament binding activity; filamin binding activity; and tropomyosin binding activity. Predicted to be involved in cardiac muscle thin filament assembly. Predicted to be located in Z disc and stress fiber. Is expressed in brain and genitourinary system. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human NEBL (nebulette). PHENOTYPE: Mice homozygous for a null allele exhibit decreased exercise tolerance and increased response of heart to exercise. [provided by MGI curators] |