| First Author | Kee HJ | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 9 | Pages | 1529-36 |
| PubMed ID | 24662306 | Mgi Jnum | J:208641 |
| Mgi Id | MGI:5563868 | Doi | 10.1016/j.febslet.2014.03.027 |
| Citation | Kee HJ, et al. (2014) Piceatannol attenuates cardiac hypertrophy in an animal model through regulation of the expression and binding of the transcription factor GATA binding factor 6. FEBS Lett 588(9):1529-36 |
| abstractText | Piceatannol is found in grapes, passion fruit, and Japanese knotweed. Piceatannol pretreatment suppresses cardiac hypertrophy induced by isoproterenol as assessed by heart weight/body weight ratio, cross-sectional area, and expression of hypertrophic markers. The anti-hypertrophic effect of piceatannol in rat neonatal cardiomyocytes is the same as that in vivo. Piceatannol inhibits lentiviral-GATA6-induced cardiomyocyte hypertrophy. Furthermore, piceatannol reduces the interaction between GATA4 and GATA6 as well as the DNA-binding activity of endogenous GATA6 in the ANP promoter. Our results suggest that piceatannol may be a novel therapeutic agent for the prevention of cardiac hypertrophy. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: GATA6physically interacts withGATA4 by anti V5 tag coimmunoprecipitation (View interaction). |
