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Allele : Ighg1<em2(IGHG1)Mvw> immunoglobulin heavy constant gamma 1 (G1m marker); endonuclease-mediated mutation 1, Michael V Wiles
Primary Identifier  MGI:6467517 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Ighg1
Strain of Origin  B6.Cg-Fcgrt<tm1Dcr> Tg(FCGRT)32Dcr/DcrJ Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/cas9 endonuclease-mediated genome editing is used to replace the mouse Ighg1 locus hinge (exon 2), CH2 (exon 3) and CH3 (exon 4) regions with a 902 bp human hinge (exon 2), CH2 (exon 3) and CH3 (exon 4) sequences while preserving the splice junctions.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • hFC,
  • hFC
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

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0 Driven By

2 Publication categories

Trail: Allele




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