Primary Identifier | IPR033356 | Type | Family |
Short Name | Reprimo |
description | Reprimo (RPRM) has been identified as a downstream effector of p53-induced cell cycle arrest at G2/M []. Overexpression of RPRM induces G2 arrest by inhibiting both Cdc2 activity and nuclear translocation of the Cdc2-cyclin B1 complex. RPRM promoter methylation has been reported in several tumours [, , ]. |