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Publication : Mouse models and type 2 diabetes: translational opportunities.

First Author  McMurray F Year  2011
Journal  Mamm Genome Volume  22
Issue  7-8 Pages  390-400
PubMed ID  21713584 Mgi Jnum  J:175704
Mgi Id  MGI:5287065 Doi  10.1007/s00335-011-9345-3
Citation  McMurray F, et al. (2011) Mouse models and type 2 diabetes: translational opportunities. Mamm Genome 22(7-8):390-400
abstractText  Type 2 diabetes prevalence is increasing worldwide. Treatments are available, but glycaemic control is not always effective in many patients. Better models are needed to create new and improved therapies and to expand our understanding of how type 2 diabetes begins and progresses. Translational research involves the transformation of knowledge from basic scientific discoveries to impacting on public health. This can allow identification of novel molecular mechanisms underlying the disease which can lead to preventative measures, biomarkers for diagnosis, or future therapies. Generation of genetically modified mice has allowed us to investigate the function of genes and develop reproducible models in which the phenotype of the animal can be tested. Mouse models have already given us insight into glucose metabolism and insulin secretion, identified novel pathways, and have been used to confirm genome-wide association studies. In this review we discuss the use of the mouse to clarify human genome-wide association study loci, understand genes and pathways involved in type 2 diabetes, and uncover novel targets for drug discovery.
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