|  Help  |  About  |  Contact Us

Protein Coding Gene : Exosc1 exosome component 1
Primary Identifier  MGI:1913833 Organism  mouse, laboratory
Chromosome  19 NCBI Gene Number  66583
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable RNA binding activity. Predicted to be involved in RNA catabolic process and RNA processing. Predicted to act upstream of or within rRNA processing. Predicted to be located in cytosol and nucleolus. Predicted to be part of nuclear exosome (RNase complex). Predicted to be active in cytoplasm. Is expressed in several structures, including cerebral cortex; early conceptus; gonad; liver; and submandibular gland primordium. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1F. Orthologous to human EXOSC1 (exosome component 1).
PHENOTYPE: Embryos homozygous for a knock-out allele are able to implant and form an egg cylinder but are developmentally delayed, show increased epiblast cell apoptosis, and fail to initiate gastrulation. [provided by MGI curators]
  • synonyms:
  • Exosc1,
  • AI447561,
  • expressed sequence AI447561,
  • MGI:1913871,
  • RIKEN cDNA 2610312F07 gene,
  • MGI:1914932,
  • 2610312F07Rik,
  • RIKEN cDNA 2610104C07 gene,
  • RIKEN cDNA 2610035C18 gene,
  • exosome component 1,
  • 2610104C07Rik,
  • MGI:2147537,
  • 2610035C18Rik
Paste the following link
Lists
This ProteinCodingGene isn't in any lists. Upload a list.

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

10 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For





MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom