| Primary Identifier | IPR030224 | Type | Family |
| Short Name | Sla2_fam |
| description | The Sla2 family, also known as Sla2p/HIP1/HIP1R family, includes Sla2 from budding yeasts [], End4 from fission yeasts [], and Huntingtin-interacting protein 1 (HIP1) and HIP1-related (HIP1R) from humans and mice []. They are adaptor proteins that link actin to clathrin and endocytosis in the clathrin-mediated endocytosis (CME) pathway. They contain the ENTH and ANTH (E/ANTH) domain that binds both inositol phospholipids and proteins and contributes to the nucleation and formation of clathrin coats on membranes []. They may bind to actin through their I/LWEQ (talin-like) domain []. |
