| First Author | Finke D | Year | 2002 |
| Journal | Immunity | Volume | 17 |
| Issue | 3 | Pages | 363-73 |
| PubMed ID | 12354388 | Mgi Jnum | J:111436 |
| Mgi Id | MGI:3653989 | Doi | 10.1016/s1074-7613(02)00395-3 |
| Citation | Finke D, et al. (2002) CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5. Immunity 17(3):363-73 |
| abstractText | CD4+CD3- cells are the predominant hematopoietic cells found in mouse fetal intestine. We prove their role as Peyer's patch (PP)-inducing cells by transfer into neonatal PP-deficient mice. To test the requirement of chemokines and adhesion molecules in induction of PP, we studied mice deficient in CXCR5 and/or alpha4beta1 integrin-mediated adhesion. CXCR5-/- mice have CD4+CD3- cells, which are inefficient in inducing PP formation. We show here that CXCR5/CXCL13 signaling activates alpha4beta1 integrin on CD4+CD3- cells. Blocking of beta1 integrin or VCAM-1, the ligand of alpha4beta1 integrin, inhibits PP formation. This study demonstrates the link between chemokine receptors and adhesion molecules that regulates stromal/hematopoietic cell interaction leading to PP formation. |
