| First Author | Hendricks TJ | Year | 2003 |
| Journal | Neuron | Volume | 37 |
| Issue | 2 | Pages | 233-47 |
| PubMed ID | 12546819 | Mgi Jnum | J:81450 |
| Mgi Id | MGI:2449367 | Doi | 10.1016/s0896-6273(02)01167-4 |
| Citation | Hendricks TJ, et al. (2003) Pet-1 ETS Gene Plays a Critical Role in 5-HT Neuron Development and Is Required for Normal Anxiety-like and Aggressive Behavior. Neuron 37(2):233-47 |
| abstractText | The central serotonin (5-HT) neurotransmitter system is an important modulator of diverse physiological processes and behaviors; however, the transcriptional mechanisms controlling its development are largely unknown. The Pet-1 ETS factor is a precise marker of developing and adult 5-HT neurons and is expressed shortly before 5-HT appears in the hindbrain. Here we show that in mice lacking Pet-1, the majority of 5-HT neurons fail to differentiate. Remaining ones show deficient expression of genes required for 5-HT synthesis, uptake, and storage. Significantly, defective development of the 5-HT system is followed by heightened anxiety-like and aggressive behavior in adults. These findings indicate that Pet-1 is a critical determinant of 5-HT neuron identity and implicate a Pet-1-dependent program in serotonergic modulation of behavior. |
