| First Author | Matsumoto M | Year | 2016 |
| Journal | Cell Immunol | Volume | 304-305 |
| Pages | 59-62 | PubMed ID | 27131737 |
| Mgi Jnum | J:309514 | Mgi Id | MGI:6756911 |
| Doi | 10.1016/j.cellimm.2016.04.007 | Citation | Matsumoto M, et al. (2016) Moesin regulates neutrophil rolling velocity in vivo. Cell Immunol 304-305:59-62 |
| abstractText | During inflammation, the selectin-induced slow rolling of neutrophils on venules cooperates with chemokine signaling to mediate neutrophil recruitment into tissues. Previous studies identified P-selectin glycoprotein ligand-1 (PSGL-1) and CD44 as E-selectin ligands that activate integrins to induce slow rolling. We show here that in TNF-alpha-treated cremaster muscle venules, slow leukocyte rolling was impaired in mice deficient in moesin, a member of the ezrin-radixin-moesin (ERM) family. Accordingly, neutrophil recruitment in a peritonitis model was decreased in moesin-deficient mice when chemokine signaling was blocked with pertussis toxin. These results suggest that moesin contributes to the slow rolling and subsequent recruitment of neutrophils during inflammation. |
