mice intranasally infected with the Middle East respiratory syndrome coronavirus (MERS-CoV; 1-001-MERS-IS-2015001 from the Korea Centers for Disease Control and Prevention) are permissive to infection and show increased morbidity, mortality, and proinflammatory cytokine and chemokine expression viral RNA levels increased in the brain, spleen, and intestine at 6 dpi of MERS-CoV-infected mice, however, only low or unchanged viral gene expression is seen in the liver
