| First Author | Redina OE | Year | 1994 |
| Journal | Genet Res | Volume | 63 |
| Issue | 3 | Pages | 183-7 |
| PubMed ID | 8082835 | Mgi Jnum | J:19657 |
| Mgi Id | MGI:68309 | Doi | 10.1017/s001667230003233x |
| Citation | Redina OE, et al. (1994) Phenotypic expression of the fused (Fu) gene in chimaeric mice. Genet Res 63(3):183-7 |
| abstractText | The dominant gene Fused (Fu) produces skeletal abnormalities during embryonic development. It was previously shown that C57BL/6 mice contain a suppressor of Fu, which acts after fertilization. Chimaeras were used to study whether this gene would suppress the Fu phenotype after the 8-cell stage of embryo development. We found no effect of the suppressor gene on Fu phenotype (its degree and frequency of expression) in chimaeric mice. We conclude that either the suppressor gene from C57BL/6 mice can only influence Fu expression at the intracellular level or Fu expression is determined before the 8-cell embryonic stage. |
