| Primary Identifier | MGI:88121 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 11998 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; neuropeptide hormone activity; and vasopressin receptor binding activity. Predicted to be involved in several processes, including intracellular signal transduction; negative regulation of cell communication; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within vasoconstriction. Predicted to be located in dendrite and extracellular region. Predicted to be active in extracellular space and neuronal dense core vesicle. Is expressed in several structures, including alimentary system; cardiovascular system; integumental system; nervous system; and sensory organ. Used to study neurohypophyseal diabetes insipidus. Human ortholog(s) of this gene implicated in cocaine dependence; diabetes insipidus; heroin dependence; and neurohypophyseal diabetes insipidus. Orthologous to human AVP (arginine vasopressin). PHENOTYPE: Mice homozygous for a premature stop mutation display postnatal lethality. Heterozygous mice display polyuria, increased water intake, decreased urine osmolality, and hypothalamic abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
