| First Author | LaVail MM | Year | 1987 |
| Journal | Invest Ophthalmol Vis Sci | Volume | 28 |
| Issue | 7 | Pages | 1043-8 |
| PubMed ID | 3596986 | Mgi Jnum | J:99553 |
| Mgi Id | MGI:3582937 | Citation | LaVail MM, et al. (1987) Genetic regulation of light damage to photoreceptors. Invest Ophthalmol Vis Sci 28(7):1043-8 |
| abstractText | Albino mice of different inbred strains have been exposed to constant fluorescent lighting at an illuminance level of 115-130 ft-c for intervals of 1-6 weeks. Under these conditions the photoreceptors in retinas of albino BALB/cByJ mice rapidly degenerate, whereas the photoreceptors in retinas of albino C57BL/6J-c2J mice are remarkably more resistant to light damage. F1 heterozygotes produced from these two strains display an intermediate degree of light-induced degeneration. These findings demonstrate that phenotypically identical populations with different genetic constitutions can show markedly different sensitivities to light, and that genetic factors must now be included as a determinant for the severity of light damage. |
