| Primary Identifier | MGI:1891125 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 57814 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable potassium channel activity; potassium channel inhibitor activity; and transmembrane transporter binding activity. Predicted to contribute to delayed rectifier potassium channel activity and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Predicted to be involved in several processes, including potassium ion export across plasma membrane; regulation of heart rate by cardiac conduction; and ventricular cardiac muscle cell action potential. Predicted to act upstream of or within potassium ion transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in heart and heart ventricle. Orthologous to human KCNE4 (potassium voltage-gated channel subfamily E regulatory subunit 4). PHENOTYPE: Homozygous deletion of this gene impairs cardiac ventricular repolarization in an age and sex-dependent manner, with a prolonged QT interval only occurring similarly in both males and females after female menopause. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
