| First Author | Unniraman S | Year | 2004 |
| Journal | Nat Immunol | Volume | 5 |
| Issue | 11 | Pages | 1117-23 |
| PubMed ID | 15489857 | Mgi Jnum | J:93537 |
| Mgi Id | MGI:3057247 | Doi | 10.1038/ni1127 |
| Citation | Unniraman S, et al. (2004) Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc. Nat Immunol 5(11):1117-23 |
| abstractText | Chromosomal translocations involving immunoglobulin heavy chain (Igh) switch regions and an oncogene such as Myc represent initiating events in the development of many B cell malignancies. These translocations are widely thought to result from aberrant class-switch recombination. To test this model, we measured translocations in mice deficient in activation-induced cytidine deaminase (AID) that lack class-switch recombination. We found that AID made no measurable contribution to the generation of initial translocations, indicating that the intrinsic fragility of the switch regions or a pathway unrelated to AID is responsible for these translocations. In contrast, the outgrowth of translocation-positive cells was dependent on AID, raising the possibility that AID is important in tumor progression, perhaps by virtue of its mutagenic properties. |
