| First Author | Takeuchi T | Year | 2021 |
| Journal | Nature | Volume | 595 |
| Issue | 7868 | Pages | 560-564 |
| PubMed ID | 34262176 | Mgi Jnum | J:334857 |
| Mgi Id | MGI:7287759 | Doi | 10.1038/s41586-021-03727-5 |
| Citation | Takeuchi T, et al. (2021) Acetate differentially regulates IgA reactivity to commensal bacteria. Nature 595(7868):560-564 |
| abstractText | The balance between bacterial colonization and its containment in the intestine is indispensable for the symbiotic relationship between humans and their bacteria. One component to maintain homeostasis at the mucosal surfaces is immunoglobulin A (IgA), the most abundant immunoglobulin in mammals(1,2). Several studies have revealed important characteristics of poly-reactive IgA(3,4), which is produced naturally without commensal bacteria. Considering the dynamic changes within the gut environment, however, it remains uncertain how the commensal-reactive IgA pool is shaped and how such IgA affects the microbial community. Here we show that acetate-one of the major gut microbial metabolites-not only increases the production of IgA in the colon, but also alters the capacity of the IgA pool to bind to specific microorganisms including Enterobacterales. Induction of commensal-reactive IgA and changes in the IgA repertoire by acetate were observed in mice monocolonized with Escherichia coli, which belongs to Enterobacterales, but not with the major commensal Bacteroides thetaiotaomicron, which suggests that acetate directs selective IgA binding to certain microorganisms. Mechanistically, acetate orchestrated the interactions between epithelial and immune cells, induced microbially stimulated CD4 T cells to support T-cell-dependent IgA production and, as a consequence, altered the localization of these bacteria within the colon. Collectively, we identified a role for gut microbial metabolites in the regulation of differential IgA production to maintain mucosal homeostasis. |
