| Primary Identifier | IPR029593 | Type | Family |
| Short Name | Shc3/ShcC/N-Shc |
| description | The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].Shc3 (also known as NShc from neuronal Shc) mediates neurotrophin and other neuronal signallings in the central nervous system [, ]. |
