| Primary Identifier | MGI:1934811 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 98415 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including DNA binding activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including intracellular glucose homeostasis; positive regulation of transcription by RNA polymerase II; and regulation of insulin receptor signaling pathway. Acts upstream of or within glucose homeostasis and positive regulation of insulin receptor signaling pathway. Located in cytoplasm and nucleus. Part of chromatin. Is expressed in central nervous system; embryo; liver; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human NUCKS1 (nuclear casein kinase and cyclin dependent kinase substrate 1). PHENOTYPE: Homozygous KO leads to increased body fat, reduced energy expenditure, hypoactivity, reduced glucose tolerance, increased insulin levels and insulin resistance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
