| Primary Identifier | IPR041150 | Type | Domain |
| Short Name | Cdh1_DBD |
| description | This domain can be found in chromodomain helicase DNA-binding protein 1 (Chd1) present in Saccharomyces cerevisiae. Cdh1 proteins have been associated with the efficient assembly and spacing of nucleosomes []. Chd1 consists of a double chromodomain, an Snf2-related ATPase domain and a C-terminal DNA binding domain [, ].This domain comprises the first four helices of the Chd1 DNA binding domain, which can be divided into regions SANT, HL1 and the β-linker. The HL1 region comprises of some 40 residues specific to budding yeast that are unlikely to form such a prominent feature or perform a conserved function in other species. Basic residues on the alpha-1 helix are thought to be important for DNA interaction [].This domain is also found in the Hrp3 protein, another member of the Cdh1 family in Schizosaccharomyces pombe. Like Cdh1, Hrp3 also comprises two chromo-domains, SNF2-like ATPase/7 helicase domains, and a C-terminal DNA binding domain []. |
