| First Author | Brown FD | Year | 2019 |
| Journal | Nat Immunol | Volume | 20 |
| Issue | 12 | Pages | 1668-1680 |
| PubMed ID | 31636464 | Mgi Jnum | J:305771 |
| Mgi Id | MGI:6706474 | Doi | 10.1038/s41590-019-0515-x |
| Citation | Brown FD, et al. (2019) Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling. Nat Immunol 20(12):1668-1680 |
| abstractText | Lymph node fibroblastic reticular cells (FRCs) respond to signals from activated T cells by releasing nitric oxide, which inhibits T cell proliferation and restricts the size of the expanding T cell pool. Whether interactions with FRCs also support the function or differentiation of activated CD8(+) T cells is not known. Here we report that encounters with FRCs enhanced cytokine production and remodeled chromatin accessibility in newly activated CD8(+) T cells via interleukin-6. These epigenetic changes facilitated metabolic reprogramming and amplified the activity of pro-survival pathways through differential transcription factor activity. Accordingly, FRC conditioning significantly enhanced the persistence of virus-specific CD8(+) T cells in vivo and augmented their differentiation into tissue-resident memory T cells. Our study demonstrates that FRCs play a role beyond restricting T cell expansion-they can also shape the fate and function of CD8(+) T cells. |
